6YEF

70S initiation complex with assigned rRNA modifications from Staphylococcus aureus

これはPDB形式変換不可エントリーです。

6YEF の概要

• エントリーDOI: 10.2210/pdb6yef/pdb
• EMDBエントリー: 10791
• 分子名称: 16S rRNA, ribosomal protein uS10, 30S ribosomal protein S11, ... (54 entities in total)
• 機能のキーワード: rrna modifications, 70s, initiation complex, s. aureus, ribosome
• 由来する生物種: Staphylococcus aureus subsp. aureus NCTC 8325; 詳細
• タンパク質・核酸の鎖数: 52
• 化学式量合計: 2181505.10

構造登録者

Fatkhullin, B.,Golubev, A.,Khusainov, I.,Yusupova, G.,Yusupov, M. (登録日: 2020-03-24, 公開日: 2021-01-27, 最終更新日: 2025-03-12)

主引用文献

Golubev, A.,Fatkhullin, B.,Khusainov, I.,Jenner, L.,Gabdulkhakov, A.,Validov, S.,Yusupova, G.,Yusupov, M.,Usachev, K.
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 angstrom resolution.
Febs Lett., 594:3551-3567, 2020

PubMed Abstract: Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for new drugs and treatments. As the majority of antibiotics target the ribosome, knowledge of its detailed structure is crucial for drug development. Here, we report the cryo-EM reconstruction at 3.2 Å resolution of the S. aureus ribosome with P-site tRNA, messenger RNA, and 10 RNA modification sites previously not assigned or visualized. The resulting model is the most precise and complete high-resolution structure to date of the S. aureus 70S ribosome with functional ligands.

PubMed: 32852796
DOI: 10.1002/1873-3468.13915

実験手法

ELECTRON MICROSCOPY (3.2 Å)