6Y9S

Crystal structure of GSK-3b in complex with the imidazo[1,5-a]pyridine-3-carboxamide inhibitor 16

6Y9S の概要

• エントリーDOI: 10.2210/pdb6y9s/pdb
• 分子名称: Glycogen synthase kinase-3 beta, ~{N}-(oxan-4-ylmethyl)-6-(5-propan-2-yloxypyridin-3-yl)imidazo[1,5-a]pyridine-3-carboxamide, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: glycogen synthase kinase-3 beta, indazole, inhibitor, kinase, transferase, proteros biostructures gmbh
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80731.61

構造登録者

Krapp, S.,Griessner, A.,Blaesse, M.,Buonfiglio, R.,Ombrato, R. (登録日: 2020-03-10, 公開日: 2020-05-20)

• 主引用文献: Buonfiglio, R.,Prati, F.,Bischetti, M.,Cavarischia, C.,Furlotti, G.,Ombrato, R.; Discovery of Novel Imidazopyridine GSK-3 beta Inhibitors Supported by Computational Approaches.; Molecules, 25:-, 2020; PubMed: 32380735; DOI: 10.3390/molecules25092163

実験手法

X-RAY DIFFRACTION (2.03 Å)