6Y5D

Structure of human cGAS (K394E) bound to the nucleosome

Summary for 6Y5D

• Entry DOI: 10.2210/pdb6y5d/pdb
• EMDB information: 10694 11005 11006
• Descriptor: Histone H3.2, Histone H4, Histone H2A type 2-A, ... (9 entities in total)
• Functional Keywords: cgas, sting, nucleosome, innate immunity, cgmp-amp, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 22
• Total formula weight: 478344.03

Authors

Pathare, G.R.,Cavadini, S.,Kempf, G.,Thoma, N.H. (deposition date: 2020-02-25, release date: 2020-09-23, Last modification date: 2020-12-09)

• Primary citation: Pathare, G.R.,Decout, A.,Gluck, S.,Cavadini, S.,Makasheva, K.,Hovius, R.,Kempf, G.,Weiss, J.,Kozicka, Z.,Guey, B.,Melenec, P.,Fierz, B.,Thoma, N.H.,Ablasser, A.; Structural mechanism of cGAS inhibition by the nucleosome.; Nature, 587:668-672, 2020; PubMed: 32911482; DOI: 10.1038/s41586-020-2750-6

Experimental method

ELECTRON MICROSCOPY (4.1 Å)