6Y4N
Structure of Tubulin Tyrosine Ligase in Complex with Tb116
Summary for 6Y4N
Entry DOI | 10.2210/pdb6y4n/pdb |
Descriptor | Tubulin alpha-1B chain, (2~{R})-1-methylpiperidine-2-carboxylic acid, [(1~{R},3~{R})-1-(4-methanoyl-1,3-thiazol-2-yl)-4-methyl-3-(methylamino)pentyl] ethanoate, ... (18 entities in total) |
Functional Keywords | ttl, tubulin, ligase, complex |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265537.38 |
Authors | Gavrilyuk, J.,Nocek, B.,Rigol, S.,Nicolaou, K.C.,Stoll, V. (deposition date: 2020-02-21, release date: 2021-03-31, Last modification date: 2024-06-19) |
Primary citation | Nicolaou, K.C.,Pan, S.,Pulukuri, K.K.,Ye, Q.,Rigol, S.,Erande, R.D.,Vourloumis, D.,Nocek, B.P.,Munneke, S.,Lyssikatos, J.,Valdiosera, A.,Gu, C.,Lin, B.,Sarvaiaya, H.,Trinidad, J.,Sandoval, J.,Lee, C.,Hammond, M.,Aujay, M.,Taylor, N.,Pysz, M.,Purcell, J.W.,Gavrilyuk, J. Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis. J.Org.Chem., 86:3377-3421, 2021 Cited by PubMed: 33544599DOI: 10.1021/acs.joc.0c02755 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.852 Å) |
Structure validation
Download full validation report