6Y4M

Structure of Tubulin Tyrosine Ligase in Complex with Tb111

6Y4M の概要

• エントリーDOI: 10.2210/pdb6y4m/pdb
• 分子名称: Tubulin alpha-1B chain, (2~{R})-1-methylpiperidine-2-carboxylic acid, [(1~{R},3~{R})-1-acetyloxy-1-[4-methanoyl-5-(2-phenylmethoxyethyl)-2,3-dihydro-1,3-thiazol-2-yl]-4-methyl-pentan-3-yl]-methyl-azanium, ... (16 entities in total)
• 機能のキーワード: ttl, tubulin, ligase, complex
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265376.99

構造登録者

Gavrilyuk, J.,Nocek, B.,Rigol, S.,Nicolaou, K.C.,Stoll, V. (登録日: 2020-02-21, 公開日: 2021-03-31, 最終更新日: 2024-06-19)

• 主引用文献: Nicolaou, K.C.,Pan, S.,Pulukuri, K.K.,Ye, Q.,Rigol, S.,Erande, R.D.,Vourloumis, D.,Nocek, B.P.,Munneke, S.,Lyssikatos, J.,Valdiosera, A.,Gu, C.,Lin, B.,Sarvaiaya, H.,Trinidad, J.,Sandoval, J.,Lee, C.,Hammond, M.,Aujay, M.,Taylor, N.,Pysz, M.,Purcell, J.W.,Gavrilyuk, J.; Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.; J.Org.Chem., 86:3377-3421, 2021; PubMed: 33544599; DOI: 10.1021/acs.joc.0c02755

実験手法

X-RAY DIFFRACTION (3.34 Å)