6Y0K
Sulfite oxidase from Thermus thermophilus with coordinated phosphate
This is a non-PDB format compatible entry.
Summary for 6Y0K
| Entry DOI | 10.2210/pdb6y0k/pdb |
| Descriptor | Putaitve sulfite oxidase, (MOLYBDOPTERIN-S,S)-OXO-MOLYBDENUM, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | molybdoenzyme, sulfite oxidase, oxidoreductase |
| Biological source | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
| Total number of polymer chains | 1 |
| Total formula weight | 44409.56 |
| Authors | Djeghader, A.,Soulimane, T. (deposition date: 2020-02-08, release date: 2020-08-05, Last modification date: 2024-01-24) |
| Primary citation | Djeghader, A.,Rossotti, M.,Abdulkarim, S.,Biaso, F.,Gerbaud, G.,Nitschke, W.,Schoepp-Cothenet, B.,Soulimane, T.,Grimaldi, S. Structural evidence for a reaction intermediate mimic in the active site of a sulfite dehydrogenase. Chem.Commun.(Camb.), 56:9850-9853, 2020 Cited by PubMed Abstract: By combining X-ray crystallography, electron paramagnetic resonance techniques and density functional theory-based modelling, we provide evidence for a direct coordination of the product analogue, phosphate, to the molybdenum active site of a sulfite dehydrogenase. This interaction is mimicking the still experimentally uncharacterized reaction intermediate proposed to arise during the catalytic cycle of this class of enzymes. This work opens new perspectives for further deciphering the reaction mechanism of this nearly ubiquitous class of oxidoreductases. PubMed: 32716419DOI: 10.1039/d0cc03634j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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