6XYU
Update of AChE from Drosophila Melanogaster complex with tacrine derivative 9-(3-iodobenzylamino)-1,2,3,4-tetrahydroacridine
Replaces: 1QONSummary for 6XYU
| Entry DOI | 10.2210/pdb6xyu/pdb |
| Related | 6xys |
| Descriptor | Acetylcholinesterase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE, ... (5 entities in total) |
| Functional Keywords | acetylcholinesterase, insect, inhibitor, complex, hydrolase |
| Biological source | Drosophila melanogaster (Fruit fly) |
| Total number of polymer chains | 1 |
| Total formula weight | 65782.00 |
| Authors | Nachon, F.,Sussman, J.L. (deposition date: 2020-01-31, release date: 2020-03-18, Last modification date: 2024-01-24) |
| Primary citation | Nachon, F.,Rosenberry, T.L.,Silman, I.,Sussman, J.L. A Second Look at the Crystal Structures ofDrosophila melanogasterAcetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides. Molecules, 25:-, 2020 Cited by PubMed: 32155891DOI: 10.3390/molecules25051198 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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