6XV3
CRYSTAL STRUCTURE OF BRD4-BD1 WITH COMPOUND 3
Summary for 6XV3
Entry DOI | 10.2210/pdb6xv3/pdb |
Related | 6XUZ |
Descriptor | Bromodomain-containing protein 4, 3-methyl-6-[6-[(3~{S})-3-methylmorpholin-4-yl]-1-[(1~{S})-1-phenylethyl]imidazo[4,5-c]pyridin-2-yl]-~{N}-propan-2-yl-[1,2,4]triazolo[4,3-a]pyrazin-8-amine (3 entities in total) |
Functional Keywords | bromodomain, inhibitor, complex, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 62444.00 |
Authors | Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-01-21, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Platzer, G.,Mayer, M.,Beier, A.,Bruschweiler, S.,Fuchs, J.E.,Engelhardt, H.,Geist, L.,Bader, G.,Schorghuber, J.,Lichtenecker, R.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B.,Konrat, R. PI by NMR: Probing CH-pi Interactions in Protein-Ligand Complexes by NMR Spectroscopy. Angew.Chem.Int.Ed.Engl., 59:14861-14868, 2020 Cited by PubMed: 32421895DOI: 10.1002/anie.202003732 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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