6XUZ

CRYSTAL STRUCTURE OF BRD4-BD1 WITH COMPOUND 4

6XUZ の概要

• エントリーDOI: 10.2210/pdb6xuz/pdb
• 分子名称: Bromodomain-containing protein 4, 6-[1-[(2~{S})-1-methoxypropan-2-yl]-6-[(3~{S})-3-methylmorpholin-4-yl]imidazo[4,5-c]pyridin-2-yl]-3-methyl-~{N}-propan-2-yl-[1,2,4]triazolo[4,3-a]pyrazin-8-amine (3 entities in total)
• 機能のキーワード: bromodomain, inhibitor, complex, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15578.96

構造登録者

Bader, G.,Kessler, D.,Wolkerstorfer, B. (登録日: 2020-01-21, 公開日: 2020-07-08, 最終更新日: 2024-01-24)

• 主引用文献: Platzer, G.,Mayer, M.,Beier, A.,Bruschweiler, S.,Fuchs, J.E.,Engelhardt, H.,Geist, L.,Bader, G.,Schorghuber, J.,Lichtenecker, R.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B.,Konrat, R.; PI by NMR: Probing CH-pi Interactions in Protein-Ligand Complexes by NMR Spectroscopy.; Angew.Chem.Int.Ed.Engl., 59:14861-14868, 2020; PubMed: 32421895; DOI: 10.1002/anie.202003732

実験手法

X-RAY DIFFRACTION (1.07 Å)