6XUH

Crystal structure of human phosphoglucose isomerase in complex with inhibitor

Summary for 6XUH

Entry DOI	10.2210/pdb6xuh/pdb
Descriptor	Glucose-6-phosphate isomerase, 5-PHOSPHOARABINONIC ACID, (2R,3R,4S)-5-((2-aminoethyl)amino)-2,3,4-trihydroxy-5-oxopentyl dihydrogen phosphate, ... (4 entities in total)
Functional Keywords	enzyme inhibitor, phosphate, monosaccharide, phosphoglucose isomerase, autocrine motility factor, isomerase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	252951.07
Authors	Li de la Sierra-Gallay, I.,Ahmad, L.,Plancqueel, S.,van Tilbeurgh, H.,Salmon, L. (deposition date: 2020-01-20, release date: 2020-07-29, Last modification date: 2024-01-24)
Primary citation	Ahmad, L.,Plancqueel, S.,Lazar, N.,Korri-Youssoufi, H.,Li de la Sierra-Gallay, I.,van Tilbeurgh, H.,Salmon, L. Novel N-substituted 5-phosphate-d-arabinonamide derivatives as strong inhibitors of phosphoglucose isomerases: Synthesis, structure-activity relationship and crystallographic studies. Bioorg.Chem., 102:104048-104048, 2020 Cited by PubMed: 32682158 DOI: 10.1016/j.bioorg.2020.104048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.38 Å)

Structure validation