6XTW

HumRadA33F in complex with peptidic inhibitor 6

Summary for 6XTW

• Entry DOI: 10.2210/pdb6xtw/pdb
• Descriptor: DNA repair and recombination protein RadA, ~{N}-[2-[(2~{S})-2-[[(1~{S})-1-(4-methoxyphenyl)ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxidanylidene-ethyl]quinoline-2-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: rad51, recombinase, dna repair, dna binding protein
• Biological source: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
• Total number of polymer chains: 2
• Total formula weight: 51132.25

Authors

Fischer, G.,Marsh, M.E.,Scott, D.E.,Coyne, A.G.,Skidmore, J.,Abell, C.,Hyvonen, M. (deposition date: 2020-01-16, release date: 2021-01-27, Last modification date: 2024-01-24)

• Primary citation: Scott, D.E.,Francis-Newton, N.J.,Marsh, M.E.,Coyne, A.G.,Fischer, G.,Moschetti, T.,Bayly, A.R.,Sharpe, T.D.,Haas, K.T.,Barber, L.,Valenzano, C.R.,Srinivasan, R.,Huggins, D.J.,Lee, M.,Emery, A.,Hardwick, B.,Ehebauer, M.,Dagostin, C.,Esposito, A.,Pellegrini, L.,Perrior, T.,McKenzie, G.,Blundell, T.L.,Hyvonen, M.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.; A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.; Cell Chem Biol, 28:835-, 2021; PubMed: 33662256; DOI: 10.1016/j.chembiol.2021.02.006

Experimental method

X-RAY DIFFRACTION (2.31 Å)