6XTA

Recombinant human butyrylcholinesterase in complex with (2S)-N-[2-(1-benzylazepan-4-yl)ethyl]-2-(butylamino)-3-(1H-indol-3-yl)propanamide

Summary for 6XTA

• Entry DOI: 10.2210/pdb6xta/pdb
• Descriptor: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 62587.83

Authors

Brazzolotto, X.,Nachon, F.,Meden, A.,Knez, D.,Gobec, S. (deposition date: 2020-01-15, release date: 2020-10-28, Last modification date: 2024-01-24)

• Primary citation: Meden, A.,Knez, D.,Malikowska-Racia, N.,Brazzolotto, X.,Nachon, F.,Svete, J.,Salat, K.,Groselj, U.,Gobec, S.; Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors.; Eur.J.Med.Chem., 208:112766-112766, 2020; PubMed: 32919297; DOI: 10.1016/j.ejmech.2020.112766

Experimental method

X-RAY DIFFRACTION (2.5 Å)