6XSW

Structure of the Notch3 NRR in complex with an antibody Fab Fragment

6XSW の概要

• エントリーDOI: 10.2210/pdb6xsw/pdb
• 分子名称: Anti-N3 Fab Heavy Chain, Anti-N3 Fab Light Chain, Neurogenic locus notch homolog protein 3, ... (7 entities in total)
• 機能のキーワード: notch3, antibody, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• 由来する生物種: Rattus norvegicus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 318978.95

構造登録者

Bard, J. (登録日: 2020-07-16, 公開日: 2021-07-21, 最終更新日: 2023-10-25)

• 主引用文献: Geles, K.G.,Gao, Y.,Giannakou, A.,Sridharan, L.,Yamin, T.T.,Zhang, J.,Karim, R.,Bard, J.,Piche-Nicholas, N.,Charati, M.,Maderna, A.,Lucas, J.,Golas, J.,Guffroy, M.,Pirie-Shepherd, S.,Roy, M.,Qian, J.,Franks, T.,Zhong, W.,O'Donnell, C.J.,Tchistiakova, L.,Gerber, H.P.,Sapra, P.; NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.; Cell Rep Med, 2:100279-100279, 2021; PubMed: 34095881; DOI: 10.1016/j.xcrm.2021.100279

実験手法

X-RAY DIFFRACTION (2.98 Å)