6XPP
Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase
Summary for 6XPP
Entry DOI | 10.2210/pdb6xpp/pdb |
Descriptor | Isocitrate lyase, 2-methylidenebutanedioic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | covalent modification, lyase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 189252.40 |
Authors | Kwai, B.X.C.,Bashiri, G.,Leung, I.K.H. (deposition date: 2020-07-08, release date: 2020-10-21, Last modification date: 2023-10-18) |
Primary citation | Kwai, B.X.C.,Collins, A.J.,Middleditch, M.J.,Sperry, J.,Bashiri, G.,Leung, I.K.H. Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase. Rsc Med Chem, 12:57-61, 2021 Cited by PubMed: 34046597DOI: 10.1039/d0md00301h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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