6XPB

Structure of human GGT1 in complex with 2-amino-4-(((1-((carboxymethyl)amino)-1-oxobutan-2-yl)oxy)(phenoxy)phosphoryl)butanoic acid (ACPB) molecule

6XPB の概要

• エントリーDOI: 10.2210/pdb6xpb/pdb
• 分子名称: Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: inhibitor-enzyme complex, ntn-hydrolase family, glycoprotein, n-glycosylation, cell surface, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60370.60

構造登録者

Terzyan, S.S.,Hanigan, M.H. (登録日: 2020-07-08, 公開日: 2020-11-25, 最終更新日: 2023-10-18)

• 主引用文献: Terzyan, S.S.,Nguyen, L.T.,Burgett, A.W.G.,Heroux, A.,Smith, C.A.,You, Y.,Hanigan, M.H.; Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.; J.Biol.Chem., 296:100066-100066, 2020; PubMed: 33187988; DOI: 10.1074/jbc.RA120.016265

実験手法

X-RAY DIFFRACTION (1.74 Å)