6XP9
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC co-activator peptide IN COMPLEX WITH (S,S)-1
6XP9 の概要
エントリーDOI | 10.2210/pdb6xp9/pdb |
分子名称 | Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 fusion, (2S)-tert-butoxy[7-(8-fluoro-5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid, GLYCEROL, ... (4 entities in total) |
機能のキーワード | nuclear receptor, multiple binding modes, xenobiotic, promiscuous, ligand, nuclear hormone receptor, nuclear protein |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 80890.49 |
構造登録者 | |
主引用文献 | Sivaprakasam, P.,Wang, Z.,Meanwell, N.A.,Khan, J.A.,Langley, D.R.,Johnson, S.R.,Li, G.,Pendri, A.,Connolly, T.P.,Gao, M.,Camac, D.M.,Klakouski, C.,Zvyaga, T.,Cianci, C.,McAuliffe, B.,Ding, B.,Discotto, L.,Krystal, M.R.,Jenkins, S.,Peese, K.M.,Narasimhulu Naidu, B. Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase. Bioorg.Med.Chem.Lett., 30:127531-127531, 2020 Cited by PubMed: 32890685DOI: 10.1016/j.bmcl.2020.127531 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.27 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)