6XOX

cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970

6XOX の概要

• エントリーDOI: 10.2210/pdb6xox/pdb
• EMDBエントリー: 22283
• 分子名称: Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, single-chain variable fragment scFv16, ... (7 entities in total)
• 機能のキーワード: class b gpcr, glucagon-like peptide-1 receptor, g protein nucleotide exchange factor., membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 187033.91

構造登録者

Sun, B.,Kobilka, B.K.,Sloop, K.W.,Feng, D.,Kobilka, T.S. (登録日: 2020-07-07, 公開日: 2020-11-18, 最終更新日: 2020-12-09)

• 主引用文献: Kawai, T.,Sun, B.,Yoshino, H.,Feng, D.,Suzuki, Y.,Fukazawa, M.,Nagao, S.,Wainscott, D.B.,Showalter, A.D.,Droz, B.A.,Kobilka, T.S.,Coghlan, M.P.,Willard, F.S.,Kawabe, Y.,Kobilka, B.K.,Sloop, K.W.; Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.; Proc.Natl.Acad.Sci.USA, 117:29959-29967, 2020; PubMed: 33177239; DOI: 10.1073/pnas.2014879117

実験手法

ELECTRON MICROSCOPY (3.1 Å)