6XON

DCN1 bound to inhibitor 9

Summary for 6XON

Entry DOI	10.2210/pdb6xon/pdb
Descriptor	Lysozyme DCN1-like protein 1 chimera, (2S)-N-[(2S)-2-cyclohexyl-2-({N-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alanyl}amino)ethyl]-4-(dimethylamino)-2-methylbutanamide (3 entities in total)
Functional Keywords	inhibitor, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Enterobacteria phage T4 More
Total number of polymer chains	1
Total formula weight	44919.25
Authors	Stuckey, J.A. (deposition date: 2020-07-07, release date: 2021-06-02, Last modification date: 2023-10-18)
Primary citation	Zhou, H.,Lu, J.,Chinnaswamy, K.,Stuckey, J.A.,Liu, L.,McEachern, D.,Yang, C.Y.,Bernard, D.,Shen, H.,Rui, L.,Sun, Y.,Wang, S. Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nat Commun, 12:2621-2621, 2021 Cited by PubMed: 33976147 DOI: 10.1038/s41467-021-22924-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation