6XNP

Crystal Structure of Human STING CTD complex with SR-717

Summary for 6XNP

• Entry DOI: 10.2210/pdb6xnp/pdb
• Descriptor: Stimulator of interferon protein, 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: agonist, complex, closed conformation, immunity, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 44137.29

Authors

Chin, E.N.,Yu, C.,Wolan, D.W.,Petrassi, H.M.,Lairson, L.L. (deposition date: 2020-07-03, release date: 2020-08-26, Last modification date: 2023-10-18)

• Primary citation: Chin, E.N.,Yu, C.,Vartabedian, V.F.,Jia, Y.,Kumar, M.,Gamo, A.M.,Vernier, W.,Ali, S.H.,Kissai, M.,Lazar, D.C.,Nguyen, N.,Pereira, L.E.,Benish, B.,Woods, A.K.,Joseph, S.B.,Chu, A.,Johnson, K.A.,Sander, P.N.,Martinez-Pena, F.,Hampton, E.N.,Young, T.S.,Wolan, D.W.,Chatterjee, A.K.,Schultz, P.G.,Petrassi, H.M.,Teijaro, J.R.,Lairson, L.L.; Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.; Science, 369:993-999, 2020; PubMed: 32820126; DOI: 10.1126/science.abb4255

Experimental method

X-RAY DIFFRACTION (1.77 Å)