6XNP

Crystal Structure of Human STING CTD complex with SR-717

6XNP の概要

• エントリーDOI: 10.2210/pdb6xnp/pdb
• 分子名称: Stimulator of interferon protein, 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: agonist, complex, closed conformation, immunity, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44137.29

構造登録者

Chin, E.N.,Yu, C.,Wolan, D.W.,Petrassi, H.M.,Lairson, L.L. (登録日: 2020-07-03, 公開日: 2020-08-26, 最終更新日: 2023-10-18)

• 主引用文献: Chin, E.N.,Yu, C.,Vartabedian, V.F.,Jia, Y.,Kumar, M.,Gamo, A.M.,Vernier, W.,Ali, S.H.,Kissai, M.,Lazar, D.C.,Nguyen, N.,Pereira, L.E.,Benish, B.,Woods, A.K.,Joseph, S.B.,Chu, A.,Johnson, K.A.,Sander, P.N.,Martinez-Pena, F.,Hampton, E.N.,Young, T.S.,Wolan, D.W.,Chatterjee, A.K.,Schultz, P.G.,Petrassi, H.M.,Teijaro, J.R.,Lairson, L.L.; Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.; Science, 369:993-999, 2020; PubMed: 32820126; DOI: 10.1126/science.abb4255

実験手法

X-RAY DIFFRACTION (1.77 Å)