6XKP

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-270

Summary for 6XKP

• Entry DOI: 10.2210/pdb6xkp/pdb
• Related: 6XKQ
• Descriptor: Spike protein S1, CV07-270 Heavy Chain, CV07-270 Light Chain, ... (5 entities in total)
• Functional Keywords: sars-cov-2, antibody, spike, coronavirus, covid-19, immune system, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 148461.15

Authors

Liu, H.,Yuan, M.,Zhu, X.,Wu, N.C.,Wilson, I.A. (deposition date: 2020-06-26, release date: 2020-10-14, Last modification date: 2023-10-18)

• Primary citation: Kreye, J.,Reincke, S.M.,Kornau, H.C.,Sanchez-Sendin, E.,Corman, V.M.,Liu, H.,Yuan, M.,Wu, N.C.,Zhu, X.,Lee, C.D.,Trimpert, J.,Holtje, M.,Dietert, K.,Stoffler, L.,von Wardenburg, N.,van Hoof, S.,Homeyer, M.A.,Hoffmann, J.,Abdelgawad, A.,Gruber, A.D.,Bertzbach, L.D.,Vladimirova, D.,Li, L.Y.,Barthel, P.C.,Skriner, K.,Hocke, A.C.,Hippenstiel, S.,Witzenrath, M.,Suttorp, N.,Kurth, F.,Franke, C.,Endres, M.,Schmitz, D.,Jeworowski, L.M.,Richter, A.,Schmidt, M.L.,Schwarz, T.,Muller, M.A.,Drosten, C.,Wendisch, D.,Sander, L.E.,Osterrieder, N.,Wilson, I.A.,Pruss, H.; A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.; Cell, 183:1058-, 2020; PubMed: 33058755; DOI: 10.1016/j.cell.2020.09.049

Experimental method

X-RAY DIFFRACTION (2.72 Å)