6XKP

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-270

6XKP の概要

• エントリーDOI: 10.2210/pdb6xkp/pdb
• 関連するPDBエントリー: 6XKQ
• 分子名称: Spike protein S1, CV07-270 Heavy Chain, CV07-270 Light Chain, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, antibody, spike, coronavirus, covid-19, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 148461.15

構造登録者

Liu, H.,Yuan, M.,Zhu, X.,Wu, N.C.,Wilson, I.A. (登録日: 2020-06-26, 公開日: 2020-10-14, 最終更新日: 2023-10-18)

• 主引用文献: Kreye, J.,Reincke, S.M.,Kornau, H.C.,Sanchez-Sendin, E.,Corman, V.M.,Liu, H.,Yuan, M.,Wu, N.C.,Zhu, X.,Lee, C.D.,Trimpert, J.,Holtje, M.,Dietert, K.,Stoffler, L.,von Wardenburg, N.,van Hoof, S.,Homeyer, M.A.,Hoffmann, J.,Abdelgawad, A.,Gruber, A.D.,Bertzbach, L.D.,Vladimirova, D.,Li, L.Y.,Barthel, P.C.,Skriner, K.,Hocke, A.C.,Hippenstiel, S.,Witzenrath, M.,Suttorp, N.,Kurth, F.,Franke, C.,Endres, M.,Schmitz, D.,Jeworowski, L.M.,Richter, A.,Schmidt, M.L.,Schwarz, T.,Muller, M.A.,Drosten, C.,Wendisch, D.,Sander, L.E.,Osterrieder, N.,Wilson, I.A.,Pruss, H.; A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.; Cell, 183:1058-, 2020; PubMed: 33058755; DOI: 10.1016/j.cell.2020.09.049

実験手法

X-RAY DIFFRACTION (2.72 Å)