6XKI

Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog

Summary for 6XKI

• Entry DOI: 10.2210/pdb6xki/pdb
• Descriptor: Eukaryotic initiation factor 4A-I, RNA (5'-R(*AP*GP*AP*GP*AP*GP*AP*GP*AP*G)-3'), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
• Functional Keywords: inhibitor, rna, translation initiation, translation, translation-rna-inhibitor complex, translation/rna/inhibitor
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48740.24

Authors

Liang, J.,Naineni, S.K.,Pelletier, J.,Nagar, B. (deposition date: 2020-06-26, release date: 2021-01-06, Last modification date: 2023-10-18)

• Primary citation: Naineni, S.K.,Liang, J.,Hull, K.,Cencic, R.,Zhu, M.,Northcote, P.,Teesdale-Spittle, P.,Romo, D.,Nagar, B.,Pelletier, J.; Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.; Cell Chem Biol, 28:825-, 2021; PubMed: 33412110; DOI: 10.1016/j.chembiol.2020.12.006

Experimental method

X-RAY DIFFRACTION (2.87 Å)