6XKD

Structure of ligand-bound mouse cGAMP hydrolase ENPP1

6XKD の概要

• エントリーDOI: 10.2210/pdb6xkd/pdb
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 191818.79

構造登録者

Fernandez, D.,Li, L. (登録日: 2020-06-26, 公開日: 2021-06-02, 最終更新日: 2023-10-18)

• 主引用文献: Carozza, J.A.,Brown, J.A.,Bohnert, V.,Fernandez, D.,AlSaif, Y.,Mardjuki, R.E.,Smith, M.,Li, L.; Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP.; Cell Chem Biol, 27:1347-1358.e5, 2020; PubMed: 32726585; DOI: 10.1016/j.chembiol.2020.07.007

実験手法

X-RAY DIFFRACTION (3.2 Å)