6XID

PCSK9(deltaCRD) in complex with cyclic peptide 51

6XID の概要

• エントリーDOI: 10.2210/pdb6xid/pdb
• 分子名称: Proprotein convertase subtilisin/kexin type 9, Peptide 51, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: protein-peptide complex, cyclic peptide, non-natural amino acids, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48219.18

構造登録者

Orth, P. (登録日: 2020-06-19, 公開日: 2020-11-18, 最終更新日: 2024-04-24)

• 主引用文献: Alleyne, C.,Amin, R.P.,Bhatt, B.,Bianchi, E.,Blain, J.C.,Boyer, N.,Branca, D.,Embrey, M.W.,Ha, S.N.,Jette, K.,Johns, D.G.,Kerekes, A.D.,Koeplinger, K.A.,LaPlaca, D.,Li, N.,Murphy, B.,Orth, P.,Ricardo, A.,Salowe, S.,Seyb, K.,Shahripour, A.,Stringer, J.R.,Sun, Y.,Tracy, R.,Wu, C.,Xiong, Y.,Youm, H.,Zokian, H.J.,Tucker, T.J.; Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.; J.Med.Chem., 63:13796-13824, 2020; PubMed: 33170686; DOI: 10.1021/acs.jmedchem.0c01084

実験手法

X-RAY DIFFRACTION (1.482 Å)