6XEV

CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2

Summary for 6XEV

Entry DOI	10.2210/pdb6xev/pdb
EMDB information	22150 22151 22152 22153 22154 22155
Descriptor	G protein-activated inward rectifier potassium channel 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, CHOLESTEROL HEMISUCCINATE, ... (5 entities in total)
Functional Keywords	cryoem, girk, inwardly rectifying potassium channel, cholesterol, lipids, pip2, transport protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	161781.23
Authors	Mathiharan, Y.K.,Glaaser, I.W.,Skiniotis, G.,Slesinger, P.A. (deposition date: 2020-06-14, release date: 2021-09-01, Last modification date: 2024-11-20)
Primary citation	Mathiharan, Y.K.,Glaaser, I.W.,Zhao, Y.,Robertson, M.J.,Skiniotis, G.,Slesinger, P.A. Structural insights into GIRK2 channel modulation by cholesterol and PIP2 Cell Rep, 36:109619-, 2021 Cited by DOI: 10.1016/j.celrep.2021.109619 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation