6XEV

CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2

6XEV の概要

• エントリーDOI: 10.2210/pdb6xev/pdb
• EMDBエントリー: 22150 22151 22152 22153 22154 22155
• 分子名称: G protein-activated inward rectifier potassium channel 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, CHOLESTEROL HEMISUCCINATE, ... (5 entities in total)
• 機能のキーワード: cryoem, girk, inwardly rectifying potassium channel, cholesterol, lipids, pip2, transport protein
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161781.23

構造登録者

Mathiharan, Y.K.,Glaaser, I.W.,Skiniotis, G.,Slesinger, P.A. (登録日: 2020-06-14, 公開日: 2021-09-01, 最終更新日: 2024-11-20)

• 主引用文献: Mathiharan, Y.K.,Glaaser, I.W.,Zhao, Y.,Robertson, M.J.,Skiniotis, G.,Slesinger, P.A.; Structural insights into GIRK2 channel modulation by cholesterol and PIP2; Cell Rep, 36:109619-, 2021; DOI: 10.1016/j.celrep.2021.109619

実験手法

ELECTRON MICROSCOPY (3.5 Å)