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6XEB

STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH KETONE INHIBITOR (COMPOUND E)

Summary for 6XEB
Entry DOI10.2210/pdb6xeb/pdb
DescriptorHistone deacetylase 2, ZINC ION, SULFATE ION, ... (7 entities in total)
Functional Keywordshistone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total formula weight132698.83
Authors
Klein, D.J.,Clausen, D. (deposition date: 2020-06-12, release date: 2020-08-12, Last modification date: 2024-03-06)
Primary citationClausen, D.J.,Liu, J.,Yu, W.,Duffy, J.L.,Chung, C.C.,Myers, R.W.,Klein, D.J.,Fells, J.,Holloway, K.,Wu, J.,Wu, G.,Howell, B.J.,Barnard, R.J.O.,Kozlowski, J.
Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Bioorg.Med.Chem.Lett., 30:127367-127367, 2020
Cited by
PubMed: 32738976
DOI: 10.1016/j.bmcl.2020.127367
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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