6XDT
Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 5-((2-formyl-4-methoxyphenoxy)methyl)picolinate
Summary for 6XDT
| Entry DOI | 10.2210/pdb6xdt/pdb |
| Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total) |
| Functional Keywords | hemoglobin, aromatic aldehyde, antisickling, allosteric effector, oxygen transport |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 65233.71 |
| Authors | Pagare, P.P.,Safo, M.K.,Musayev, F.N. (deposition date: 2020-06-11, release date: 2020-12-02, Last modification date: 2023-10-18) |
| Primary citation | Pagare, P.P.,Ghatge, M.S.,Chen, Q.,Musayev, F.N.,Venitz, J.,Abdulmalik, O.,Zhang, Y.,Safo, M.K. Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents. J.Med.Chem., 63:14724-14739, 2020 Cited by PubMed: 33205981DOI: 10.1021/acs.jmedchem.0c01287 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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