6XCG

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934

6XCG の概要

• エントリーDOI: 10.2210/pdb6xcg/pdb
• 分子名称: Histone-lysine N-methyltransferase NSD2, N-cyclopropyl-3-oxo-N-({4-[(pyrimidin-4-yl)carbamoyl]phenyl}methyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carboxamide, UNKNOWN ATOM OR ION, ... (4 entities in total)
• 機能のキーワード: nsd2-pwwp, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49770.30

構造登録者

Zhou, M.Q.,Dong, A.,Ingerman, L.A.,Hanley, R.P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2020-06-08, 公開日: 2020-07-22, 最終更新日: 2023-10-18)

• 主引用文献: Dilworth, D.,Hanley, R.P.,Ferreira de Freitas, R.,Allali-Hassani, A.,Zhou, M.,Mehta, N.,Marunde, M.R.,Ackloo, S.,Carvalho Machado, R.A.,Khalili Yazdi, A.,Owens, D.D.G.,Vu, V.,Nie, D.Y.,Alqazzaz, M.,Marcon, E.,Li, F.,Chau, I.,Bolotokova, A.,Qin, S.,Lei, M.,Liu, Y.,Szewczyk, M.M.,Dong, A.,Kazemzadeh, S.,Abramyan, T.,Popova, I.K.,Hall, N.W.,Meiners, M.J.,Cheek, M.A.,Gibson, E.,Kireev, D.,Greenblatt, J.F.,Keogh, M.C.,Min, J.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Barsyte-Lovejoy, D.,James, L.I.,Schapira, M.; A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.; Nat.Chem.Biol., 18:56-63, 2022; PubMed: 34782742; DOI: 10.1038/s41589-021-00898-0

実験手法

X-RAY DIFFRACTION (1.64 Å)