6XAR
Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2)
Summary for 6XAR
Entry DOI | 10.2210/pdb6xar/pdb |
Descriptor | E3 ubiquitin-protein ligase CBL, Src-like-adapter 2, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | adaptor, e3 ubiquitin ligase, activation, complex, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 81880.28 |
Authors | Wybenga-Groot, L.E.,McGlade, C.J. (deposition date: 2020-06-04, release date: 2021-03-03, Last modification date: 2023-10-18) |
Primary citation | Wybenga-Groot, L.E.,Tench, A.J.,Simpson, C.D.,Germain, J.S.,Raught, B.,Moran, M.F.,McGlade, C.J. SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. J.Mol.Biol., 433:166880-166880, 2021 Cited by PubMed: 33617900DOI: 10.1016/j.jmb.2021.166880 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.501 Å) |
Structure validation
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