6XAE
SUBSTITUTED BENZYLOXYTRICYCLIC COMPOUNDS AS RETINOIC ACID-RELATED ORPHAN RECEPTOR GAMMA T AGONISTS
Replaces: 6W9JSummary for 6XAE
Entry DOI | 10.2210/pdb6xae/pdb |
Descriptor | Nuclear receptor ROR-gamma, trans-4-{(3aR,9bR)-7-[(2-chloro-6-fluorophenyl)methoxy]-9b-[(4-fluorophenyl)sulfonyl]-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl}cyclohexane-1-carboxylic acid (3 entities in total) |
Functional Keywords | rorgt, nuclear hormone receptor, ligand-binding domain, inve agonist, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33531.05 |
Authors | Sack, J.S. (deposition date: 2020-06-04, release date: 2020-06-17, Last modification date: 2023-10-18) |
Primary citation | Harikrishnan, L.S.,Gill, P.,Kamau, M.G.,Qin, L.Y.,Ruan, Z.,O'Malley, D.,Huynh, T.,Stachura, S.,Cavallaro, C.L.,Lu, Z.,J-W Duan, J.,Weigelt, C.A.,Sack, J.S.,Ruzanov, M.,Khan, J.,Gururajan, M.,Wong, J.J.,Huang, Y.,Yarde, M.,Li, Z.,Chen, C.,Sun, H.,Borowski, V.,Murtaza, A.,Fink, B.E. Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (ROR gamma t) agonists. Bioorg.Med.Chem.Lett., 30:127204-127204, 2020 Cited by PubMed: 32334911DOI: 10.1016/j.bmcl.2020.127204 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.257 Å) |
Structure validation
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