6XAE
SUBSTITUTED BENZYLOXYTRICYCLIC COMPOUNDS AS RETINOIC ACID-RELATED ORPHAN RECEPTOR GAMMA T AGONISTS
Replaces: 6W9JEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 285 | 32886.9 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B (A) | trans-4-{(3aR,9bR)-7-[(2-chloro-6-fluorophenyl)methoxy]-9b-[(4-fluorophenyl)sulfonyl]-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl}cyclohexane-1-carboxylic acid | non-polymer | 644.1 | 1 | Chemie (Z7F) | |||
| 3 | C (A) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 265 - 508 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Met 244 | - | expression tag |
| Gly 245 | - | expression tag |
| Ser 246 | - | expression tag |
| Ser 247 | - | expression tag |
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| Ser 254 | - | expression tag |
| Ser 255 | - | expression tag |
| Gly 256 | - | expression tag |
| Leu 257 | - | expression tag |
| Val 258 | - | expression tag |
| Pro 259 | - | expression tag |
| Arg 260 | - | expression tag |
| Gly 261 | - | expression tag |
| Ser 262 | - | expression tag |
| His 263 | - | expression tag |
| Met 264 | - | expression tag |
| Ser 509 | - | expression tag |
| Gly 510 | - | expression tag |
| Gly 511 | - | expression tag |
| Ser 512 | - | expression tag |
| Gly 513 | - | expression tag |
| Gly 514 | - | expression tag |
| Leu 515 | - | expression tag |
| Thr 516 | - | expression tag |
| Glu 517 | - | expression tag |
| Arg 518 | - | expression tag |
| His 519 | - | expression tag |
| Lys 520 | - | expression tag |
| Ile 521 | - | expression tag |
| Leu 522 | - | expression tag |
| His 523 | - | expression tag |
| Arg 524 | - | expression tag |
| Leu 525 | - | expression tag |
| Leu 526 | - | expression tag |
| Gln 527 | - | expression tag |
| Glu 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32886.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 644.1 | |
| All* | Total formula weight | 33531.0 |
