6XA9
SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide
Summary for 6XA9
Entry DOI | 10.2210/pdb6xa9/pdb |
Descriptor | Non-structural protein 3, ISG15 CTD-propargylamide, GLYCEROL, ... (5 entities in total) |
Functional Keywords | sars cov-2, papain-like protease, isg15ctd activity based probe, covid19, hydrolase-substrate complex, hydrolase/substrate |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 6 |
Total formula weight | 135954.60 |
Authors | Klemm, T.,Calleja, D.J.,Richardson, L.W.,Lechtenberg, B.C.,Komander, D. (deposition date: 2020-06-04, release date: 2020-06-17, Last modification date: 2023-10-18) |
Primary citation | Klemm, T.,Ebert, G.,Calleja, D.J.,Allison, C.C.,Richardson, L.W.,Bernardini, J.P.,Lu, B.G.,Kuchel, N.W.,Grohmann, C.,Shibata, Y.,Gan, Z.Y.,Cooney, J.P.,Doerflinger, M.,Au, A.E.,Blackmore, T.R.,van der Heden van Noort, G.J.,Geurink, P.P.,Ovaa, H.,Newman, J.,Riboldi-Tunnicliffe, A.,Czabotar, P.E.,Mitchell, J.P.,Feltham, R.,Lechtenberg, B.C.,Lowes, K.N.,Dewson, G.,Pellegrini, M.,Lessene, G.,Komander, D. Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. Embo J., 39:e106275-e106275, 2020 Cited by PubMed: 32845033DOI: 10.15252/embj.2020106275 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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