6X9O

High resolution cryoEM structure of huntingtin in complex with HAP40

6X9O の概要

• エントリーDOI: 10.2210/pdb6x9o/pdb
• EMDBエントリー: 22106
• 分子名称: Huntingtin, 40-kDa huntingtin-associated protein (2 entities in total)
• 機能のキーワード: huntingtin, htt, 40-kda huntingtin-associated protein, hap40, structural genomics, structural genomics consortium, sgc, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 390814.60

構造登録者

Harding, R.J.,Deme, J.C.,Lea, S.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (登録日: 2020-06-03, 公開日: 2020-06-17, 最終更新日: 2022-03-30)

• 主引用文献: Harding, R.J.,Deme, J.C.,Hevler, J.F.,Tamara, S.,Lemak, A.,Cantle, J.P.,Szewczyk, M.M.,Begeja, N.,Goss, S.,Zuo, X.,Loppnau, P.,Seitova, A.,Hutchinson, A.,Fan, L.,Truant, R.,Schapira, M.,Carroll, J.B.,Heck, A.J.R.,Lea, S.M.,Arrowsmith, C.H.; Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.; Commun Biol, 4:1374-1374, 2021; PubMed: 34880419; DOI: 10.1038/s42003-021-02895-4

実験手法

ELECTRON MICROSCOPY (2.6 Å)