6X8E

Crystal structure of JAK2 with Compound 11

Summary for 6X8E

Entry DOI	10.2210/pdb6x8e/pdb
Descriptor	Tyrosine-protein kinase JAK2, [3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1H-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile (3 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	70950.19
Authors	Vajdos, F.F.,Knafels, J.D. (deposition date: 2020-06-01, release date: 2020-11-25, Last modification date: 2023-11-15)
Primary citation	Gerstenberger, B.S.,Ambler, C.,Arnold, E.P.,Banker, M.E.,Brown, M.F.,Clark, J.D.,Dermenci, A.,Dowty, M.E.,Fensome, A.,Fish, S.,Hayward, M.M.,Hegen, M.,Hollingshead, B.D.,Knafels, J.D.,Lin, D.W.,Lin, T.H.,Owen, D.R.,Saiah, E.,Sharma, R.,Vajdos, F.F.,Xing, L.,Yang, X.,Yang, X.,Wright, S.W. Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases. J.Med.Chem., 63:13561-13577, 2020 Cited by PubMed: 32787094 DOI: 10.1021/acs.jmedchem.0c00948 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation