6X7B
BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P
Summary for 6X7B
Entry DOI | 10.2210/pdb6x7b/pdb |
Descriptor | Bromodomain-containing protein 4, 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide (3 entities in total) |
Functional Keywords | brd4, pi3k, cdk4/6, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32717.62 |
Authors | Vann, K.R.,Kutateladze, T.G. (deposition date: 2020-05-29, release date: 2020-08-05, Last modification date: 2023-10-18) |
Primary citation | Vann, K.R.,Pal, D.,Morales, G.A.,Burgoyne, A.M.,Durden, D.L.,Kutateladze, T.G. Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep, 10:12027-12027, 2020 Cited by PubMed: 32694708DOI: 10.1038/s41598-020-68964-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.951 Å) |
Structure validation
Download full validation report