6X4T
Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain
Summary for 6X4T
Entry DOI | 10.2210/pdb6x4t/pdb |
Descriptor | ICOS ligand, Prezalumab Fab Heavy chain, Prezalumab Fab Light chain, ... (7 entities in total) |
Functional Keywords | immune checkpoint, immune system, receptor ligand, glycoprotein, antibody, b cell |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 179458.11 |
Authors | Rujas, E.,Sicard, T.,Julien, J.P. (deposition date: 2020-05-23, release date: 2020-10-14, Last modification date: 2023-10-18) |
Primary citation | Rujas, E.,Cui, H.,Sicard, T.,Semesi, A.,Julien, J.P. Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11:5066-5066, 2020 Cited by PubMed: 33033255DOI: 10.1038/s41467-020-18828-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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