6X4I

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with 3'-uridinemonophosphate

6X4I の概要

• エントリーDOI: 10.2210/pdb6x4i/pdb
• 関連するPDBエントリー: 6VWW 6W01 6WLC 6WXC 6X1B
• 分子名称: Uridylate-specific endoribonuclease, 3'-URIDINEMONOPHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: sars corona virus 2, endoribonuclease, covid-19, structural genomics, center for structural genomics of infectious diseases, csgid, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85227.19

構造登録者

Chang, C.,Kim, Y.,Maltseva, N.,Jedrzejczak, R.,Endres, M.,Michalska, K.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2020-05-22, 公開日: 2020-06-03, 最終更新日: 2023-10-18)

• 主引用文献: Kim, Y.,Wower, J.,Maltseva, N.,Chang, C.,Jedrzejczak, R.,Wilamowski, M.,Kang, S.,Nicolaescu, V.,Randall, G.,Michalska, K.,Joachimiak, A.; Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.; Commun Biol, 4:193-193, 2021; PubMed: 33564093; DOI: 10.1038/s42003-021-01735-9

実験手法

X-RAY DIFFRACTION (1.85 Å)