6X4G

Crystal structure of ICOS in complex with ICOS-L and an anti ICOS-L VNAR domain

Summary for 6X4G

• Entry DOI: 10.2210/pdb6x4g/pdb
• Descriptor: Inducible T-cell costimulator, ICOS ligand, anti ICOS-L VHH domain VNAR, ... (6 entities in total)
• Functional Keywords: immune checkpoint, receptors, glycoproteins, immune system, t-cell, b-cell
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 57412.44

Authors

Rujas, E.,Sicard, T.,Julien, J.P. (deposition date: 2020-05-22, release date: 2020-10-14, Last modification date: 2023-10-18)

• Primary citation: Rujas, E.,Cui, H.,Sicard, T.,Semesi, A.,Julien, J.P.; Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.; Nat Commun, 11:5066-5066, 2020; PubMed: 33033255; DOI: 10.1038/s41467-020-18828-4

Experimental method

X-RAY DIFFRACTION (3.5 Å)