6X2J
Structure of human TRPA1 in complex with agonist GNE551
Summary for 6X2J
Entry DOI | 10.2210/pdb6x2j/pdb |
EMDB information | 22009 |
Descriptor | Transient receptor potential cation channel subfamily A member 1, 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide (2 entities in total) |
Functional Keywords | trpa1, channel, agonist, membrane protein, membrane protein-agonist complex, membrane protein/agonist |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 292289.55 |
Authors | |
Primary citation | Liu, C.,Reese, R.,Vu, S.,Rouge, L.,Shields, S.D.,Kakiuchi-Kiyota, S.,Chen, H.,Johnson, K.,Shi, Y.P.,Chernov-Rogan, T.,Greiner, D.M.Z.,Kohli, P.B.,Hackos, D.,Brillantes, B.,Tam, C.,Li, T.,Wang, J.,Safina, B.,Magnuson, S.,Volgraf, M.,Payandeh, J.,Zheng, J.,Rohou, A.,Chen, J. A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron, 109:273-284.e4, 2021 Cited by PubMed: 33152265DOI: 10.1016/j.neuron.2020.10.014 PDB entries with the same primary citation |
Experimental method |
Structure validation
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