6X1Y

Mre11 dimer in complex with small molecule modulator PFMI

6X1Y の概要

• エントリーDOI: 10.2210/pdb6x1y/pdb
• 分子名称: Nuclease SbcCD subunit D, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, ... (4 entities in total)
• 機能のキーワード: dna repair mre11 thermophilic nuclease, dna double-strand break repair, hydrolase
• 由来する生物種: Thermotoga maritima
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78043.55

構造登録者

Arvai, A.S.,Moiani, D.,Tainer, J.A. (登録日: 2020-05-19, 公開日: 2020-06-10, 最終更新日: 2023-10-18)

• 主引用文献: Wilson 3rd, D.M.,Deacon, A.M.,Duncton, M.A.J.,Pellicena, P.,Georgiadis, M.M.,Yeh, A.P.,Arvai, A.S.,Moiani, D.,Tainer, J.A.,Das, D.; Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.; Prog.Biophys.Mol.Biol., 163:130-142, 2021; PubMed: 33115610; DOI: 10.1016/j.pbiomolbio.2020.10.005

実験手法

X-RAY DIFFRACTION (2.35 Å)