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6X1F

Tubulin-RB3_SLD-TTL in complex with compound 5m

Summary for 6X1F
Entry DOI10.2210/pdb6x1f/pdb
DescriptorTubulin alpha-1B chain, 7-methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywordsmicrotubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological sourceRattus norvegicus (Rat)
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Total number of polymer chains6
Total formula weight264987.17
Authors
White, S.W.,Yun, M. (deposition date: 2020-05-18, release date: 2021-09-22, Last modification date: 2023-10-18)
Primary citationBanerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D.
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
J.Med.Chem., 64:13072-13095, 2021
Cited by
PubMed: 34406768
DOI: 10.1021/acs.jmedchem.1c01202
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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