6X0S

Structure of human plasma factor XIIa in complex with (2S)-4-(5-chloro-1,3-benzoxazol-2-yl)-1-(N,3-dicyclohexyl-D-alanyl)-N-[(thiophen-2-yl)methyl]piperazine-2-carboxamide (compound 7)

Summary for 6X0S

• Entry DOI: 10.2210/pdb6x0s/pdb
• Descriptor: Coagulation factor XII, (2S)-4-(5-chloro-1,3-benzoxazol-2-yl)-1-(N,3-dicyclohexyl-D-alanyl)-N-[(thiophen-2-yl)methyl]piperazine-2-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: preotease, blood clotting, inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 85742.44

Authors

Orth, P. (deposition date: 2020-05-17, release date: 2021-05-19, Last modification date: 2023-10-18)

• Primary citation: Rao, A.U.,Chu, H.D.; Structure of human plasma factor XIIa in complex with (2S)-4-(5-chloro-1,3-benzoxazol-2-yl)-1-(N,3-dicyclohexyl-D-alanyl)-N-[(thiophen-2-yl)methyl]piperazine-2-carboxamide (compound 7); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.898 Å)