6WXJ

CSF1R signaling is a regulator of pathogenesis in progressive MS

Summary for 6WXJ

• Entry DOI: 10.2210/pdb6wxj/pdb
• Descriptor: Macrophage colony-stimulating factor 1 receptor, 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine (3 entities in total)
• Functional Keywords: csf1r, inhibitor, tki, ms, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 38178.60

Authors

Liu, J. (deposition date: 2020-05-10, release date: 2021-02-10, Last modification date: 2023-10-18)

• Primary citation: Hagan, N.,Kane, J.L.,Grover, D.,Woodworth, L.,Madore, C.,Saleh, J.,Sancho, J.,Liu, J.,Li, Y.,Proto, J.,Zelic, M.,Mahan, A.,Kothe, M.,Scholte, A.A.,Fitzgerald, M.,Gisevius, B.,Haghikia, A.,Butovsky, O.,Ofengeim, D.; CSF1R signaling is a regulator of pathogenesis in progressive MS.; Cell Death Dis, 11:904-904, 2020; PubMed: 33097690; DOI: 10.1038/s41419-020-03084-7

Experimental method

X-RAY DIFFRACTION (2.62 Å)