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6WVP

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GF

Summary for 6WVP
Entry DOI10.2210/pdb6wvp/pdb
Related6WU1 6WUV 6WUY 6WUZ 6WVC 6WVO
DescriptorAcetylcholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsnerve agent, acetylcholinesterase, tabun, ga, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight120945.22
Authors
McGuire, J.R.,Bester, S.M.,Pegan, S.D.,Height, J.J. (deposition date: 2020-05-06, release date: 2021-02-17, Last modification date: 2023-10-18)
Primary citationMcGuire, J.R.,Bester, S.M.,Guelta, M.A.,Cheung, J.,Langley, C.,Winemiller, M.D.,Bae, S.Y.,Funk, V.,Myslinski, J.M.,Pegan, S.D.,Height, J.J.
Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.
Chem.Res.Toxicol., 34:804-816, 2021
Cited by
PubMed: 33538594
DOI: 10.1021/acs.chemrestox.0c00406
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.308 Å)
Structure validation

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