6WVO

Crystal Structure of Recombinant Human Acetylcholinesterase In Complex with GD and HI-6

Summary for 6WVO

Entry DOI	10.2210/pdb6wvo/pdb
Related	6WUV 6WUY 6WUZ 6WV1 6WVC
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (9 entities in total)
Functional Keywords	nerve agent, acetylcholinesterase, tabun, ga, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	121780.12
Authors	McGuire, J.R.,Bester, S.M.,Pegan, S.D.,Height, J.J. (deposition date: 2020-05-06, release date: 2021-03-31, Last modification date: 2023-10-18)
Primary citation	McGuire, J.R.,Bester, S.M.,Guelta, M.A.,Cheung, J.,Langley, C.,Winemiller, M.D.,Bae, S.Y.,Funk, V.,Myslinski, J.M.,Pegan, S.D.,Height, J.J. Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6. Chem.Res.Toxicol., 34:804-816, 2021 Cited by PubMed: 33538594 DOI: 10.1021/acs.chemrestox.0c00406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation