6WUV
Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GA
Summary for 6WUV
Entry DOI | 10.2210/pdb6wuv/pdb |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | nerve agent, acetylcholinesterase, tabun, ga, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 121575.69 |
Authors | McGuire, J.R.,Bester, S.M.,Pegan, S.D.,Height, J.J. (deposition date: 2020-05-05, release date: 2021-02-17, Last modification date: 2023-10-18) |
Primary citation | McGuire, J.R.,Bester, S.M.,Guelta, M.A.,Cheung, J.,Langley, C.,Winemiller, M.D.,Bae, S.Y.,Funk, V.,Myslinski, J.M.,Pegan, S.D.,Height, J.J. Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6. Chem.Res.Toxicol., 34:804-816, 2021 Cited by PubMed: 33538594DOI: 10.1021/acs.chemrestox.0c00406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.63 Å) |
Structure validation
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