6WUU
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR250
Summary for 6WUU
Entry DOI | 10.2210/pdb6wuu/pdb |
Related PRD ID | PRD_002385 |
Descriptor | Non-structural protein 3, VIR250, ZINC ION, ... (5 entities in total) |
Functional Keywords | covid-19, coronavirus, sars, cov-2, papain-like protease, plpro, deubiquitinating enzyme, ubiquitin, activity-based probe, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 8 |
Total formula weight | 150889.85 |
Authors | Lv, Z.,Olsen, S.K. (deposition date: 2020-05-05, release date: 2020-05-20, Last modification date: 2023-11-15) |
Primary citation | Rut, W.,Lv, Z.,Zmudzinski, M.,Patchett, S.,Nayak, D.,Snipas, S.J.,El Oualid, F.,Huang, T.T.,Bekes, M.,Drag, M.,Olsen, S.K. Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Sci Adv, 6:-, 2020 Cited by PubMed: 33067239DOI: 10.1126/sciadv.abd4596 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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