6WTM

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Summary for 6WTM

• Entry DOI: 10.2210/pdb6wtm/pdb
• Descriptor: 3C-like proteinase (2 entities in total)
• Functional Keywords: covid-19, sars-cov-2, 3clpro, coronavirus, main protease, kinetics, sars, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 2
• Total formula weight: 67651.09

Authors

Khan, M.B.,Arutyunova, E.,Young, H.S.,Lemieux, M.J. (deposition date: 2020-05-03, release date: 2020-05-20, Last modification date: 2023-10-18)

• Primary citation: Vuong, W.,Khan, M.B.,Fischer, C.,Arutyunova, E.,Lamer, T.,Shields, J.,Saffran, H.A.,McKay, R.T.,van Belkum, M.J.,Joyce, M.A.,Young, H.S.,Tyrrell, D.L.,Vederas, J.C.,Lemieux, M.J.; Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.; Nat Commun, 11:4282-4282, 2020; PubMed: 32855413; DOI: 10.1038/s41467-020-18096-2

Experimental method

X-RAY DIFFRACTION (1.85 Å)